Zinc finger protein 804A

Zinc finger protein 804A
Identifiers
Symbol	ZNF804A
Alt. symbols	C2orf10
Entrez	91752
HUGO	21711
OMIM	612282
RefSeq	NM_194250
Other data
Locus	Chr. 2 q32.1

Zinc finger protein 804A or ZNF804A is a human protein that has a zinc finger in its structure.

Clinical significance

In a genome-wide study conducted in 2008, the rs1344706 SNP of the gene was shown to associate with schizophrenia.^[1] Later, the same SNP was reported to correlate with slightly disturbed functional coupling of several brain regions in healthy persons, according to authors, resembling the changes described in schizophrenia.^[2]

References

^ O'Donovan MC, Craddock N, Norton N, et al (September 2008). "Identification of loci associated with schizophrenia by genome-wide association and follow-up". Nat. Genet. 40 (9): 1053–5. doi:10.1038/ng.201. PMID 18677311.
^ Research published on May 1st 2009:
- Esslinger C, Walter H, Kirsch P, et al (May 2009). "Neural mechanisms of a genome-wide supported psychosis variant". Science 324 (5927): 605. doi:10.1126/science.1167768. PMID 19407193. ;
- Simple description: University of Bonn (2009, May 1). Schizophrenia And Manic-depressive Disorder: Genetic Variant Impairs Communication Within Brain. ScienceDaily. Retrieved May 3, 2009
- Schizophrenia-associated Variant in ZNF804A Gene Affects Brain Connectivity - a report at Schizophrenia Research Forum 5 may 2009, Pat McCaffrey.